Primary Sjogren’s Syndrome: A case report

Sapna Raut Dessai, Elaine Barretto


Sjogren’s syndrome is a chronic autoimmune disorder characterized by xerostomia, xerophthalmia, and lymphocytic infiltration of the exocrine glands. It is named after the Swedish ophthalmologist Henrik Sjogren who first described it as a triad of keratoconjunctivitis sicca, xerostomia and rheumatoid arthritis. Besides this triad there are various other systemic conditions which may be frequently associated with this syndrome. Besides presenting a case review, this article also reviews in detail these various other systemic conditions related and found associated with this syndrome. 


Sjogren’s syndrome, xerostomia, sicca complex, sialography, lymphoma.

Full Text:



Matos CR, Martins MRC. Sjögren’s syndrome: A Literature Review. Rev. Odonto ciênc. 2009; 24: 426-431.

Peri Y, Agmon N-Levin Emanuel Theodor Yehuda Shoenfeld. Sjögren’s Syndrome, The old and the new. Best Practice & Research Clinical Rheumatology. 2012; 26:105–117.

Gomes PD, Juodzbalys G, Fernandes MH, Guobis Z. Diagnostic approaches to Sjögren's syndrome: A literature review and own clinical experience. Journal of oral & maxillofacial research. 2012 Apr 1;3(1):e3.

Shimizu M, Okamura AK, Yoshiura AK, Ohyama Y, Nakamura CS, Kinukawa N. Sonographic Diagnostic Criteria for screening Sjögren’s Syndrome. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;102:85-93.

Obinata K, Sato T, Ohmori K, Shindo M, Nakamura M. A Comparison of diagnostic tools for Sjögren Syndrome, with emphasis on Sialography, Histopathology, and Ultrasonography. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;109:129-134.

Izumi M, Eguchi K, Ohki M, Uetani M, Hayashi K, Kita M, Nagataki S, Nakamura T. MR Imaging of the Parotid Gland in Sjogren’s Syndrome: A proposal for new diagnostic criteria. AJR 1996; 166: 1483-1487.

d'Arbonneau F, Ansart S, Berre RL, Dueymes M, Youinou P, Pennec YL. Thyroid dysfunction in primary Sjögren's syndrome: A long‐term followup study. Arthritis Care & Research. 2003 Dec 15;49(6):804-9.

Suzuki H, Hickling P, Lyons CBA. A Case of Primary Sjogren's Syndrome, complicated by Cryoglobulinaemic Glomerulonephritis, Pericardial and Pleural Effusions. British Journal of Rheumatology. 1996; 35: 72-75.

Kobayashi H, Matsuoka R, Kitamura S, Tsunoda N and Saito K. Sjögren's Syndrome with multiple bullae and pulmonary nodular amyloidosis. Chest 1988;94: 438-440.

Koh MS, Goh KYC, Chen C, Howe HS. Cerebral Infarct Mimicking Glioma in Sjogren’s Syndrome. Hong Kong Med J. 2002; 8: 292-4.

Marwah A, Mohapatra S, Handa R. Sjogren’s Syndrome presenting with Interstitial Lung disease. JAPI 2005; 53 : 153-154.

Choi W, Lee SS, Park YG, Yoon KC. A Case of Necrotizing Keratoscleritis In Primary Sjogren’s Syndrome. Korean J Ophthalmol. 2011;25:275-277

Tazi, I., M. Rachid, and S. Benchekroun. "Sjögren’s syndrome associated with multiple myeloma." Singapore Med J 49, no. 8 (2008): e215-6.

Chen SF, Chiu MJ, Su JJ. Rhombencephalitis as an Initial Manifestation of Primary Sjögren’s Syndrome: A Case Report and Review of the Literatures. Acta Neurol Taiwan. 2011 Mar;20:35-41.

Reddy KS, Jha V, Nada R, Kohli HS, Sud K, Krishan L, Gupta, Sakhuja V. Respiratory Paralysis in Sjogren Syndrome with normal renal function. The National Medical Journal of India. 2003; 16: 253 -254.

Choi YM, Sheen DH, Lee YJ, Lee EB, Song YW. Sjogren's Syndrome presenting as remitting seronegative symmetric synovitis with pitting edema (RS3PE). J Korean Med Sci. 2003; 18: 606-8.

Krstić M, Alempijević T, Andrejević S, Zlatanović M, Damjanov N, Ivanović B, Jovanović I, Tarabar D, Milosavljević T. Watermelon stomach in a patient with primary Sjögren's syndrome. Vojnosanit Pregl 2010; 67: 256–258.

Fife RS, Chase WF, Dore RK, Wiesenhutter CW, Lockhart PB, Tindall E, Suen JY. Cevimeline for the treatment of xerostomia in patients with Sjögren syndrome: a randomized trial. Arch Intern Med. 2002;162 :1293-300.

Braga MA, Tarzia O, Bergamaschi CC, Santos FA, Andrade ED, Groppo FC. Comparison of the effects of pilocarpine and cevimeline on salivary flow. International journal of dental hygiene. 2009 May 1;7(2):126-30.

Vivino FB, Al-Hashimi I, Khan Z, LeVeque FG, Salisbury PL, Tran-Johnson TK, Muscoplat CC, Trivedi M, Goldlust B, Gallagher SC. Pilocarpine Tablets for the Treatment of Dry Mouth and Dry Eye Symptoms in Patients with Sjo¨gren Syndrome. A Randomized, Placebo-Controlled, Fixed-Dose, Multicenter Trial. Arch Intern Med. 1999; 159: 174-181.

Tsifetaki N, Kitsos G, Paschides CA, Alamanos Y, Eftaxias V, Voulgari PV, Psilas K, Drosos AA. Oral pilocarpine for the treatment of ocular symptoms in patients with Sjo¨gren’s syndrome: a randomised 12 week controlled study. Ann Rheum Dis 2003; 62: 1204 –1207.

Dörner T, Goldenberg DM. Targeting CD22 as a strategy for treating systemic autoimmune diseases. Ther Clin Risk Manag. 2007; 3: 953–959.

Leonard JP, Goldenberg DM. Preclinical and clinical evaluation of epratuzumab (anti-CD22 IgG) in B-cell malignancies. Oncogene. 2007; 26: 3704–3713.


  • There are currently no refbacks.

Journal of Oral Health Research Copyright ©

eISSN 2229-6018